ODCs

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5 OMIM references -
5 associated genes
6 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
8 signs/symptoms

Hereditary persistence of fetal hemoglobin - beta-thalassemia

Huntington disease


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	HBB	(0.63)	HTT

Citations in the biomedical literature:

Hereditary persistence of fetal hemoglobin - beta-thalassemia		Huntington disease
	Synonym(s): - HPFH - beta-thalassemia		Synonym(s): - Huntington chorea

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: variable Average age of death: any age Type of inheritance: autosomal dominant

	External references: 5 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: D006816

Hereditary persistence of fetal hemoglobin - beta-thalassemia		Huntington disease
	Very frequent - Anaemia - Hemoglobinosis / hemoglobinopathy - Pallor - Splenomegaly Frequent - Anomalies of bones / skeletal anomalies - Hepatomegaly / liver enlargement (excluding storage disease)		Frequent - Abnormal cry / voice / phonation disorder / nasal speech - Autosomal dominant inheritance - Cortical atrophy without hydrocephaly / cerebral hemiatrophy / subcortical atrophy - EEG anomalies - Hypertonia / spasticity / rigidity / stiffness - Movement disorder - Psychic / behavioural troubles - Psychic / psychomotor regression / dementia / intellectual decline